For small scale screening work Syncom has access to a broad off-the-shelf enzyme collection. A group of Syncom chemists has been specially trained to screen rapidly a variety of enzyme classes to identify the most suitable enzyme for your target reaction.
In general, various biocatalytic approaches are viable for a certain process. Syncom will advice on the biocatalysis route that has the best chance of success, which is based on literature precedent and Syncom experience. Syncom will perform a proper screening using 96-well microtiterplates and simultaneously an analytical method for chiral HPLC or GC will be developed in order to streamline the process.
Syncom will report on the results and is able to develop the successful bio-transformations to effective and scalable procedures for syntheses optimized up to kilogram scale production.
Biocatalysis Platforms
- lipase, esterase, protease
- acylase
- ketoreductase
- enereductase
- hydantoinase
- amidase
- aminotransferase
- nitrilase/nitrile hydratase
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