 Partly in response to the extensive work on diastereomeric resolution carried out by Syncom we have developed great expertise with the use of chiral HPLC columns. Successful performance of such work depends on rapid access to reliable information with regard to the enantiomeric excesses.
Virtually any racemate, including those that do not have the pronounced acidic or basic character needed for Pasteur resolution, can now be separated very quickly on an analytical basis using the rapid screening protocols that we have developed. The same chromatographic techniques are used to support work on, for example, chiral pool syntheses or enantioselective catalysis. These separations can often be upscaled to preparative apparatus. Syncom also uses chiral glc for volatile compounds.
Particularly worthy of mention is the fact that Syncom is also experienced with the use of chiral exchange chromatography, a new and upcoming technique particularly suited for many chiral salts.
Syncom can also arrange testing for chiral separations on simulated moving bed (SMB) apparatus for relatively small scale scanning and assessment studies.
- Broad analytical and preparative experience
- Experienced with the use of chiral exchange chromatography
- Small scale scanning and assessment studies for SMB
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